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Available Animal Cohorts

This table lists several large studies that could either provide data for analysis, or collaborate by conducting desired analyses internally. This information can be used in helping to develop a pilot project in response to the request for applications.  The table is a work in process, and will be updated regularly.

Should you wish to list your lab/name/data in this table, please contact Dr. Kulbir Kaur.

For further details of the data, please reach out to the lab contacts listed (email provided) .

InvestigatorContactSpeciesSexBehavioral AssayBiological Data collected from all or a subset of animals
Barnes, CarolCarol BarnesF344 ratsMMorris watermaze – spatial, cued, working memory. I have large legacy datasets on these – but do have other tests on smaller numbers of animals,the data are all cross sectionalawake, behaving electrophysiology, molecular imaging (catFISH), microbiome samples, immunohistochemistry, RNAseq, and MRI scans
Bizon, Jennifer Jennifer BizonStudy 1F344 ratsMLegacy data for: watermaze (spatial and cued), spatial working memorybiochemistry (GABA/GLU mRNA and protein expression), CORT
F344 ratsMLegacy data for: watermaze (spatial and cued) and odor detection threshold and discrimination learning
F344 ratsMLegacy data for: watermaze (spatial and cued), delayed response, attentional set shifting
Study 2Fischer Brown Norway ratsMintertemporal choice, delayed response, attentional set shifting, instrumental responding on a progressive ratioRNAseq, optogentic data, pharmacology, serum cytokine
Study 3Fischer Brown Norway ratsMrisky decision making, probabilistic reversal learning resting state fMRI
Blalock, Eric Eric BlalockStudy 1F344 rats (3 mo)M, FTreatments (2x2): control vs 3 hour restraint; vehicle vs. progesterone. Morris water maze – spatial, cued, working memoryPlasma for hormone measures; brain tissue for IHC and laser capture microdissected hippocampal subregions for transcriptional profiling.
Study 2F344 rats (3 and 18 mo)MMorris water maze – spatial, cued, working memory. Transcriptional profiling of laser capture microdissected hippocampal CA1 (gray matter) and alveus (white matter). Gene signatures correlated to behavior
Study 3Nearly 30 published transcriptional profiling studies (we are actively growing the database). Raw transcriptional data downloaded from the Gene Expression Omnibus is reanalyzed for aging and AD-related transcriptional agreement across measurement platforms, labs, and animal models. We've built a comparison metric (the false concordance rate) that combines # found to agree vs # expected to agree by chance, as well as linear correlation of magnitudes of change among genes that do agree across studies. Additional pre-publication data can be compared with or added to the database
Disterhoft, JohnJohn DisterhoftStudy 1F344BN rats young adult (3-6 mo) and aged (27-32 mo)Mlarge Crossectional data: Morris watermaze – spatial, cued, working memory. Trace eyeblink conditioning – paired, pseudoconditionedBrains micro-dissected/flash frozen; Brains perfused and fixed in PFA; Mass Spectrometry Proteomic Profiling; Biophysical data from CA1 and CA3 pyramidal neurons and Layer III and Layer V Lateral Entorhinal Cortex neurons
New studyF344 and TgF344-AD rats young adult (5-7 mo), middle-aged (12-14 mo), and aged (20-22 mo)M, FMorris watermaze – spatial, cued, working memory. Trace eyeblink conditioning – paired.
Foster, Tom Tom FosterF344 ratsM, FMorris watermaze – spatial, cued, working memory. 5-choice serial reaction time task. Beacon discrimination (pattern separation). Physical measures (mainly grip strength). Most studies are cross sectional with some repeated testing (6-18 months) or twice with various delays (10 days to 1-2 months)In vitro electrophysiology (IO curves for AMPA and NMDA receptors, synaptic plasticity), considerable RNAseq from hippocampal subregions and mPFC and fMRI scans (one published study and some preliminary data
Gallagher, MichelaMichella GallagherStudy 1Long-EvansMLegacy water maze data, spatial and non-spatial. Data from a variety of smaller, purpose-designed behavioral studiesGene microarray datasets (open access data is provided to repositories (e.g. the raw uncurated data from microarray gene profiling has been deposited in the NCBI Gene Expression Omnibus (GEO) database). plasma samples, brain microdissected samples, in situ hybridization and immunohistochemical samples and analysis
Study 2Diversity Outbred (DO) miceMWater maze data, spatial and non-spatialPlasma samples, brain microdissected samples, in situ hybridization and immunohistochemical samples
Kaczorowski, Catherine Catherine KaczorowskiStudy 1C57BL6/J miceM, FLarge cross-sectional legacy datasets: Y-maze working memory, contextual fear conditioning, elevated plus maze, motor composite (incline screen, narrow beam, and grip strength) at 6 and 14 mo. New studies are adding 3 mo and 22 mo time pointsBulk RNAseq of hippocampus and prefrontal cortex (PFC). Cerebellum, hypothalamus and midbrain micro-dissected/flash frozen; peripheral organs flash frozen, hemi-brains fixed in PFA; Mass Spectrometry Proteomic Profiling; MRI (structural, functional and DTI).
Study 240+ genetically diverse, but reproducible, BXD strains and AD-BXDs strains that segregate for ~6 million DNA variantsM, FLarge cross-sectional legacy datasets: Y-maze working memory, contextual fear conditioning, elevated plus maze, motor composite (incline screen, narrow beam, and grip strength) at 6 and 14 mo. New studies are adding 3 mo and 22 mo time points
Study 3Set of 10 genetically diverse,Collaborative Cross (CC) strains that segregate for ~50 million DNA variantsM, FLarge cross-sectional legacy datasets: Contextual fear conditioning at 6, 12 and 18 mo.
500+ female Diversity Outbred (DO) mice that segregate for ~50 million DNA variants.FLarge cross-sectional legacy datasets
New data1000+ female Diversity Outbred (DO) mice that segregate for ~50 million DNA variants.FLarge longitudinal (up to 24 mo) legacy datasets: Y-maze working memory (10 and 22 mo) and contextual fear conditioning at 24 mo. Diet groups: 2 and 3-day fast, 20% and 40% caloric restriction, ad lib chow.
Rapp, Peter Peter RappLong-EvansMLegacy water maze data, spatial and non-spatial. Data from a variety of far smaller, purpose designed behavioral studiesBrains typically prepared and frozen for immunohistochemical/quantitative morphometry analysis; brains microdissected/flash frozen; plasma sample, limited other tissues

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