The conference will take place in Bethesda, MD. Make plans to join us there!
Remote access to select live plenary sessions will be made available for those who will not be able to travel.
Reminder that we await your feedback on the Framework!
October 31 – November 1, 2021
Bethesda, Maryland – USA
3rd Workshop on Research Definitions for Reserve and Resilience in Cognitive Aging and Dementia
Meet the following panelists in Bethesda who have confirmed participation:
David Bartrés-Faz, PhD, University of Barcelona
Jennifer Bizon, PhD, University of Florida
John Disterhoft, PhD, Northwestern University
Emrah Düzel, MD, German Center for Neurodegenerative Diseases
Thomas Foster, PhD, University of Florida
Timothy Hohman, PhD, Vanderbilt University
William Jagust, MD, University of California, Berkeley
Richard Jones, ScD, Brown University
Catherine Kaczorowski, PhD, The Jackson Laboratory
William Kremen, PhD, UCSD
Joseph McQuail, PhD, University of South Carolina
Thomas Montine, MD, PhD, Stanford University
Denise Park, PhD, University of Texas at Dallas
Dorene Rentz, PsyD, Harvard Medical School
Nikolaos Scarmeas, PhD, Columbia University
Yaakov Stern, Columbia University
Prashanthi Vemuri, PhD, Mayo Clinic
Lon White, MD, MPH Pacific Health Research and Education Institute
Robert Willis, PhD, University of Michigan
The goal of the Collaboratory is to come to a consensus across the research community on operational definitions to further a cohesive research goal encompassing age-related and disease related cognitive decline.
CREATE FOCUSED WORKGROUPS – Establishing workgroups that will develop strategies to address specific plan across scientific disciplines.
IDENTIFY AND FUND PILOT GRANTS – Committees to identify promising research themes and fund pilot studies.
DEVELOP DATA AND INFORMATION SHARING PLATFORMS – Creating database of datasets relevant to the definitions for collaborative analytical research.
Collaboratory on Research Definitions for Reserve and Resilience in Cognitive Aging and Dementia
Research indicates that specific life exposures and genetic factors contribute to some people being more resilient than others, with lower rates of cognitive decline with aging and reduced risk of developing Alzheimer’s disease and related dementia (ADRD). The factors associated with resilience have an important role in the development of interventions and health policies. There are likely several complex and highly interactive mechanisms that lead to these individual differences in vulnerability to decline, probably reliant on both structural and functional brain mechanisms. Investigators in this area have employed many terms encapsulating individual differences including resilience, cognitive reserve, brain reserve, brain maintenance, and compensation. In addition, there are terms commonly used in cognitive neuroscience studies of aging, such as efficiency, capacity, and compensation. However, the definitions of these concepts differ across researchers, and the translation from human to animal research is not well developed. It is important to bring together researchers from basic neuroscience to human studies to develop operational definitions for these concepts.
Along with these definitions, there is a need for translating these concepts so that they can guide research on all levels of epidemiologic, clinical, intervention, imaging and basic animal research. A particular challenge will be to identify corresponding concepts in neurobiology, animal models and models at the level of cells and molecules and approaches bridging those levels of analysis.
The three year, NIA-supported Collaboratory on Research Definitions will provide a platform for the exchange of ideas. The goal of the Collaboratory is to develop operational definitions, research guidelines, and data sharing platforms with consensus and assistance from the research community. To reach its goal the Collaboratory will hold three cross-discipline workshops that bring together investigators to discuss and come to consensus on these concepts, create focused work groups that will examine each of these issues, fund pilot grants designed to further the understanding and research applicability of these concepts, and to develop data sharing and information exchange platforms to help guide research in this area.
The Collaboratory is introducing the latest version of the Framework for Terms Used in Research of Reserve and Resilience.
Comments on this document are being invited.
Available Human and Animal Cohorts
The Collaboratory is also providing a data repository of large studies that could either provide data for analysis or collaborations.
We invite researchers to review the tables of both human and non-human cohorts available and as applicable, to submit their names/laboratories/data for inclusion.
Reserve and Resilience Investigators
Review research groups during a survey study undertaken by the Reserve, Resilience and Protective Factors Professional Interest Area (PIA) of the Alzheimer’s Association International Society to Advance Alzheimer’s Research and Treatment.
Materials from past workshops
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October 31 – November 1, 2021
Bethesda, Maryland, USA
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