4th Workshop on Research Definitions for Reserve and Resilience in Cognitive Aging & Dementia

Hybrid Event – December 4-5, 2023

Bethesda, MD, USA – Marriott Bethesda

4th Workshop on Research Definitions for Reserve and Resilience in Cognitive Aging & Dementia

The Collaboratory has been very successful in allowing us to develop consensus operational definitions for three aspects of “resilience”: cognitive reserve, brain maintenance and brain reserve. The pilot awards have generated some excellent research that provides examples of how to implement these guidelines. We now feel it would be very useful to have one final meeting that helps us think about and implement projects that share data to facilitate further research in this area.

We had experts provide practical information about various facets of data sharing, including guidance from National Institute on Aging representatives on their new data sharing requirements. A large part of the meeting was set aside for two breakout sessions. The first session focused on brainstorming about projects that would benefit from data sharing; the second session established plans for projects that participants can work on together in the future.

Our hope is that this final meeting will spark many innovative projects that will make major contributions to our understanding of the contributors to, and the neural implementation, of reserve and resilience.

PROGRAM

All times in US Eastern.

Sunday, December 3, 2023

6:00-8:00 pm

Welcome Reception

Monday, December 4, 2023

8:00-8:50am

Breakfast

8:00-8:45

Mentoring Session/Meet with Senior Researchers

9:00-9:10

Workshop – Introduction, Structure, Engagement

Yaakov Stern, PhD - Columbia University

9:10-10:05

SESSION 1 – PLENARY: Two "Framing" Talks

9:10-9:35

Creating Shareable Data to Facilitate Research in Reserve & Resilience

Marilyn Albert, PhD - Johns Hopkins University

9:35-9:50

Longitudinal Rat Project to Facilitate Research in Reserve & Resilience

Peter Rapp, PhD - NIH/NIA

9:50-10:05

Discussion

10:05-12:00

SESSION 2 – PLENARY: Nodes of Sharing

10:05-10:20

Sharing Large-scale Non-human Behavioral Research Data - Opportunities for Research

Catherine Kaczorowski, PhD - University of Michigan

10:20-10:35

Opportunities for Research Using Longitudinal Human Studies

Kristine Beate Walhovd, PhD - University of Oslo

10:35-10:50

Discussion

10:50-11:20

Coffee Break

11:20-11:40

Program Priorities in Cognitive Aging and Reserve

Jonathan King, PhD - NIH/NIA
Molly Wagster, PhD - NIH/NIA

11:40-12:00pm

Data Sharing NIA expectations

Jennie Larkin, PhD - NIH/NIA

12:00-12:25

Discussion

12:25-12:35

BREAKOUT SESSION: Introduction

Yaakov Stern, PhD - Columbia University

12:35-1:30

Lunch

1:30-4:40

SESSION 3 - BREAKOUT SESSION: NON-HUMAN AND HUMAN COHORTS
Topic 1: Overcoming Data-sharing Challenges for Planned Research
Topic 2: Generating Ideas for Reserve & Resilience Research Using Shared-data

1:30-2:30

BREAKOUT:
Non-Human Breakout Group
Data-sharing Challenges

Discussion Leaders: Carol Barnes, PhD - University of Arizona, and
Matt Huentelman, PhD - TGen
Panel: Audrey Branch, PhD - Johns Hopkins University
John Disterhoft, PhD - Northwestern University
Thomas Foster, PhD - University of Florida
Peter Rapp, PhD - NIH/NIA

1:30-2:30

BREAKOUT:
Human Breakout Group
Data-sharing Challenges

Discussion Leader: Scott Hofer, PhD - Pacific Health Research and Education Institute, Honolulu
Panel: Marilyn Albert, PhD - Johns Hopkins University
Emrah Düzel, MD, German Center for Neurodegenerative Diseases
Bill Jagust, MD – University of California, Berkeley
Christian Habeck, PhD - Columbia University
Yaakov Stern, PhD - Columbia University
Kristine Beate Walhovd, PhD - University of Oslo

2:30-3:00

Coffee Break

3:00-4:00

NON-HUMAN COHORT BREAKOUT (cont.)
Project Idea Generation

3:00-4:00

HUMAN COHORT BREAKOUT (cont.)
Project Idea Generation

Discussion Leader: Scott Hofer, PhD, Pacific Health Research and Education Institute, Honolulu
Panel: Marilyn Albert, PhD - Johns Hopkins University
Emrah Düzel, MD, German Center for Neurodegenerative Diseases
Christian Habeck, PhD - Columbia University
Bill Jagust, MD – University of California, Berkeley
Yaakov Stern, PhD - Columbia University
Kristine Beate Walhovd, PhD - University of Oslo

4:00-4:20

REPORT: Non-human Cohort Breakout Group

Discussion Leaders: Carol Barnes, PhD - University of Arizona, and
Matt Huntelman, PhD - TGen
Panel: Audrey Branch, PhD - Johns Hopkins University
John Disterhoft, PhD - Northwestern University
Thomas Foster, PhD - University of Florida
Peter Rapp, PhD - NIH/NIA

4:20-4:40

REPORT: Human Cohort Breakout Group

Discussion Leader: Scott Hofer, PhD - Pacific Health Research and Education Institute, Honolulu
Panel: Marilyn Albert, PhD - Johns Hopkins University
Emrah Düzel, MD, German Center for Neurodegenerative Diseases
Christian Habeck, PhD - Columbia University
Bill Jagust, MD – University of California, Berkeley
Yaakov Stern, PhD - Columbia University
Kristine Beate Walhovd, PhD - University of Oslo

4:40-5:15

Charge for Day 2: Developing Projects that Implement the Framework to Test Concepts of Reserve & Resilience

Yaakov Stern, PhD - Columbia University

5:15–7:30

Networking Reception

Tuesday, December 5, 2023

7:30-8:30am

Breakfast

7:45-8:30

Mentoring Session/Meet with Senior Researchers

8:30-11:30

SESSION 4 – BREAKOUT SESSION

8:30-10:00

NON-HUMAN AND HUMAN COHORT GROUPS DISCUSS CONCRETE PROJECTS

8:30-10:00

NON-HUMAN COHORT BREAKOUT
Concrete Projects from Project Ideas Generated on DAY 1

Carol Barnes, PhD - University of Arizona
Matt Huentelman, PhD - TGen

8:30-10:00

HUMAN COHORT BREAKOUT
Concrete Projects from Project Ideas Generated on DAY 1

Scott Hofer, PhD - Pacific Health Research and Education Institute, Honolulu
Yaakov Stern, PhD - Columbia University

10:00-10:30

Coffee Break

10:30-11:30

NON-HUMAN COHORT BREAKOUT
Concrete Projects from Project Ideas Generated on DAY 1

Carol Barnes, PhD - University of Arizona
Matt Huentelman, PhD - TGen

10:30-11:30

HUMAN COHORT BREAKOUT
Concrete Projects from Project Ideas Generated on DAY 1

Scott Hofer, PhD - Pacific Health Research and Education Institute, Honolulu
Yaakov Stern, PhD - Columbia University

11:30am-12:20pm

SESSION 5 – PLENARY: REPORTS

11:30-11:55

Report Non-human Breakout Group

Carol Barnes, PhD - University of Arizona
Matt Huentelman, PhD - Tgen

11:55am-12:20pm

Report Human Breakout Group

Scott Hofer, PhD - Pacific Health Research and Education Institute, Honolulu
Yaakov Stern, PhD - Columbia University

12:20-12:30

Conclusions/Next Steps

Yaakov Stern, PhD - Columbia University

12:30-2:00

Lunch

Workgroups established at the workshop:

Contributions of Modifiable Lifestyle Factors Across the Life Course to Cognitive Resilience

Stacy Andersen, Boston University Chobanian & Avedisian School of Medicine
Mahederemariam Dagne, Marymount University
Seo-Eun Choi, University of Wisconsin
Yian Gu, Columbia University Irving Medical Center
Patricia Heyn, Marymount University
Phillip Hwang, Boston University
Jinshil Hyun, Einstein Medical Center
Sarah James, University College London
Oshadi Jayakody, Albert Einstein College of Medicine
Quinn Kennedy, NeuroFit
Sara Mondini, University of Padova
Taylor Pedersen, Washington University in St. Louis
Nikolaos Scarmeas, National and Kapodistrian University of Athens/Columbia University
Leila Simanijoni, Columbia University Irving Medical Center
Jingkai Wei, University of South Carolina
Roger Wong

Functional Network

Meishan Ai, Northeastern University
Rory Boyle, Massachusetts General Hospital
Annabell Coors, Columbia University Irving Medical Center
Annachiara Crocetta, University of Turin
Emrah Duezel, German Center for Neurodegenerative Diseases
Michelle Eliason, University at Buffalo
Yunglin Gazes, Columbia University Irving Medical Center
Christian Habeck, Columbia University
Fatemeh Hasanzadeh, Columbia University
Bill Jagust, University of California, Berkeley
Osamu Katayama, Columbia University
Yeshin Kim, Kangwon National University Hospital
Xenia Kobeleva, RUB
Jessica Kraft, University of Texas at Dallas
Seonjoo Lee, Columbia University
Yin Liu, Utah State University
Sara Nolin, Medical University of South Carolina
Deirdre OShea, University of Miami
Zerrin Yildirim, Istanbul University
Sara Mondini, University of Padova
Taylor Pedersen, Washington University in St. Louis
Nikolaos Scarmeas, National and Kapodistrian University of Athens/Columbia University
Leila Simanijoni, Columbia University Irving Medical Center
Jingkai Wei, University of South Carolina
Roger Wong

Molecular

David Fernando Aguillon Nino, Grupo de Neurociencias de Antioquia, Universidad de Antioquia
Wyllians Borelli, UFRGS
Isabel Castanho, BIDMC, Harvard Medical School
Winston Hide, Beth Israel Deaconess Hospital
Tain Luquez, Columbia University
Thomas Hugentobler-Schilckmann, Universidade Federal do Rio Grande do Sul
Alvin Thomas, UNC Chapel Hill
Angeliki Tsapanou, Columbia University

Multifactor Associations with Intercept and Change of Brain and Cognition

Vahan Aslanyan, University of Southern California
Thakshila Dasanayake, Pennsylvania State University
Naiara Demnitz, Copenhagen University Hospital
Rebecca Egerton, Queen’s University Belfast, Centre for Public Health
Tessa Harrison, UC Berkeley
Jihyeon Jo, Seoul National University
Hanna Lu, The Chinese University of Hong Kong
Sara Mondini, University of Padova
Maira Okada de Oliveira, Mass General Hospital
Valentin Ourry, Mcgill University
Vanessa Peixoto, Federal University of Rio Grande do Norte
Stefania Pezzoli, University of California, Berkeley
Kristine Beate Walhovd, University of Oslo
Robert Willis, University of Michigan

Non-Human Cohorts

Martine Ammassari-Teule, CNR-National Research Council of Italy
Audrey Branch, Johns Hopkins University
Margherita De Introna, Tor Vergata University, Santa Lucia Foundation
John Disterhoft, Northwestern University
Thomas Foster, University of Florida
Anna Gillespie, University of Washington
David Horovitz, David Horovitz
Matt Huentelman, TGen
Michell Jin, Columbia University
Catherine Kaczorowski, University of Michigan
Joseph McQuail, University of South Carolina
Lori Newman, Vassar College
Carol Barnes, University of Arizona
Peter Rapp, NIH/NIA
Irina Sinakevitch, University of Arizona, EMBI
Cintia Velázquez Delgado, UNAM
Qianli Xue, Johns Hopkins University

Physical Activity and Level/Rate of Change in Blood-based Markers of Inflammation and Neurodegeneration

Yian Gu, Columbia University Irving Medical Center
Shivangi Jain, AdventHealth Research Institute Orlando
Corinne Pettigrew, Johns Hopkins University School of Medicine
Anja Soldan, Johns Hopkins University School of Medicine
Anna Vandebunte, UCSF Memory and Aging Center

Sociocultural Factors and Cognitive Resilience

Nawal Alsereahi, Penn State
Patricia Alzola Bordón, University of Salamanca
Katherine Britt, the University of Pennsylvania
Victor Eukuta
Alice Gavarrete Olvera, Columbia University
Renata Kochhan
Sonia Montemurro
Harry Moore, Catholic University of Murcia (UCAM)
Sharon Simon, Columbia University
Iris Strangmann, Columbia University Medical Center

Women's Reproductive Influences on the Spectrum of Dementia and Memory

Kaitlin Casaletto, UCSF
Karly Cody, Stanford University
Alexander Ehrenberg, University of California, Berkeley
Brandon Gavett, UC Davis
Linda Lorenz, Amsterdam UMC
Thomas Morin, Mass. General Hospital